Urotensin II: Its Function in Health and Its Role in Disease
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Title Urotensin II: Its function in health and its role in disease
Urotensin II (U-II) is the most potent vasoconstrictor known, even more potent than endothelin-1. It was first isolated from the fish spinal cord and has been recognized as a hormone in the neurosecretory system of teleost fish for over 30 years. After the identification of U-II in humans and the orphan human G-protein-coupled receptor 14 as the urotensin II receptor, UT, many studies have show...
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15 صفحه اولThe Role of Urotensin II in Health and Disease
Urotensin II (UII) is an 11 amino acid cyclic peptide originally isolated from the goby fish. The amino acid sequence of UII is exceptionally conserved across most vertebrate taxa, sharing structural similarity to somatostatin. UII binds to a class of G-protein coupled receptor known as GPR14 or the urotensin receptor (UT). UII and its receptor UT are widely expressed throughout the cardiovascu...
متن کاملRole of urotensin II in health and disease.
Urotensin II (UII) is an 11 amino acid cyclic peptide originally isolated from the goby fish. The amino acid sequence of UII is exceptionally conserved across most vertebrate taxa, sharing structural similarity to somatostatin. UII binds to a class of G protein-coupled receptor known as GPR14 or the urotensin receptor (UT). UII and its receptor, UT, are widely expressed throughout the cardiovas...
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ژورنال
عنوان ژورنال: Cardiovascular Drugs and Therapy
سال: 2005
ISSN: 0920-3206,1573-7241
DOI: 10.1007/s10557-005-6899-x