Urotensin-II and UII-receptor expression and function in the rat adrenal cortex
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Urotensin-II and UII-receptor expression and function in the rat adrenal cortex.
Urotensin-II (UII) is a potent hypertensive peptide, which has been recognized as an endogenous ligand of the G protein-coupled receptor (GPR)-14, now named UT-R. Real-time PCR demonstrated the expression of UII and UT-R mRNAs in both dispersed and in vitro cultured rat adrenocortical cells. UII concentration-dependently decreased basal, but not ACTH-stimulated, corticosterone secretion from cu...
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We cloned cDNAs encoding urotensin II (UII)-related peptide (URP) and UII in Japanese eel, Anguilla japonica, the former being the first such cloning in teleost fishes. Unlike the exclusive expression of UII in the urophysis, the URP gene was expressed most abundantly in the brain (medulla oblongata) followed by the urophysis. Peripheral injections of URP into eels increased blood pressure by 1...
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We studied single nucleotide polymorphisms (SNPs) and haplotypes in the urotensin-II (UTS2) and urotensin-II receptor gene (UTS2R) in Hong Kong Chinese (224 hypertensive and 306 normotensive unrelated subjects) and their relation to hypertension and the metabolic syndrome. For UTS2, the GGT haplotype (–605G, 143G, 3836T) was associated with higher plasma level of U-II and insulin, and higher ho...
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ژورنال
عنوان ژورنال: International Journal of Molecular Medicine
سال: 2006
ISSN: 1107-3756,1791-244X
DOI: 10.3892/ijmm.17.6.1111