Urocortin 2 infusion in human heart failure
نویسندگان
چکیده
منابع مشابه
Urocortin 2 infusion in human heart failure.
AIMS To document the haemodynamic, neurohormonal, and renal responses to Urocortin 2 (UCN2) infused in human heart failure (HF). METHODS AND RESULTS Eight male patients with HF [left ventricular ejection fraction (LVEF) < 40%, NYHA class II-III] received placebo and 25 [low dose (LD)] and 100 microg [high dose (HD)] of UCN2 intravenously over 1 h in a single-blind, placebo-controlled, dose-es...
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BACKGROUND The urocortins are emerging as potentially important contributors to neurohumoral regulation of the circulation with recent reports attributing a powerful array of hemodynamic, renal, and neurohumoral effects to the urocortins in cardiac failure. These peptides also seem to have cardioprotective effects in the setting of ischemia-reperfusion. Little is known concerning the plasma con...
متن کاملPlasma urocortin in human systolic heart failure.
Urocortin (UCN), a member of the corticotrophin-releasing factor family, is expressed in heart, brain and gut. UCN has potent cardiostimulatory, cardioprotective, vasodilator and diuretic/natriuretic effects, and cardiac UCN expression is increased in heart failure (HF). In the present study, we investigated plasma levels of UCN in 119 patients with HF and 212 age- and gender-matched controls t...
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AIMS Urocortin 2 and urocortin 3 may play a role in the pathophysiology of heart failure and are emerging therapeutic targets. We aimed to examine the local and systemic cardiovascular effects of urocortin 2 and urocortin 3 in healthy subjects and patients with heart failure. METHODS Patients with heart failure (n = 8) and age and gender-matched healthy subjects (n = 8) underwent bilateral fo...
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related enzymes in isolated brain microvessels. Proc Natl Acad Sci USA 72: 4622, 1975 32. Palmer GC: /3-adrenergic receptors mediate adenylate cyclase responses in rat cerebral capillaries. Neuropharmacology 19: 17, 1980 33. Herbst TJ, Raichle ME, Ferrendelli JA: ,3-adrenergic regulation of adenosine 3'-5'-monophosphate concentration in brain microvessels. Science 204: 330, 1979 34. MacKenzie E...
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 2007
ISSN: 0195-668X,1522-9645
DOI: 10.1093/eurheartj/ehm340