URMC-099 facilitates amyloid-β clearance in a murine model of Alzheimer’s disease
نویسندگان
چکیده
منابع مشابه
Effect of rosiglitazone on amyloid precursor protein processing and Aβ clearance in streptozotocin-induced rat model of Alzheimer’s disease
Objective(s): Increasing evidence suggests that Alzheimer’s disease (AD) is associated with diabetes. Rosiglitazone, a peroxisome proliferator-activated receptor γ (PPAR-γ) agonist and anti-diabetic agent, may improve symptoms of AD. However, the underlying therapeutic potential of it has not been fully elucidated. Materials and Methods: Rats were divided into four groups: control group, sham o...
متن کاملVarenicline Ameliorates Learning and Memory Deficits in Amyloid β(25–35) Rat Model of Alzheimer’s Disease
Introduction: Alzheimer’s disease (AD) is a enfeeble neurodegenerative disorder characterized by increased β-amyloid (Aβ) deposition and neuronal dysfunction leading to impaired learning and recall. Among proposed risk factors, impaired cholinergic transmission is a main cause for incidence of disease. Methods: In the present study, effects of the intracerebroventricularly administration of an ...
متن کاملHybrid FMT-CT imaging of amyloid-β plaques in a murine Alzheimer's disease model
The need to study molecular and functional parameters of Alzheimer's disease progression in animal models has led to the development of disease-specific fluorescent markers. However, curved optical interfaces and a highly heterogeneous internal structure make quantitative fluorescence imaging of the murine brain a particularly challenging tomographic problem. We investigated the integration of ...
متن کاملRosmarinic acid mitigates learning and memory disturbances in amyloid β(25–35)-induced model of Alzheimer’s disease in rat
Abstract Background and Objective: Alzheimer’s disease (AD) is a weakening neurodegenerative disorder typified by increased b-amyloid (Ab) deposition and neuronal dysfunction causing to impaired learning and memory. Among proposed risk factors, induced oxidative stress is a main cause for incidence of the disease. The aim of this study was to determine the effects of the rosmarinic acid on lear...
متن کاملNeurobiology of Disease Enhancing Astrocytic Lysosome Biogenesis Facilitates A Clearance and Attenuates Amyloid Plaque Pathogenesis
Qingli Xiao,1 Ping Yan,1 Xiucui Ma,2,3 Haiyan Liu,2 Ronaldo Perez,1 Alec Zhu,1 Ernesto Gonzales,1 Jack M. Burchett,1 Dorothy R. Schuler,1 John R. Cirrito,1 Abhinav Diwan,2,3* and Jin-Moo Lee1* 1Department of Neurology and the Hope Center for Neurological Disorders and 2Division of Cardiology and Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, Missouri 63...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Neuroinflammation
سال: 2018
ISSN: 1742-2094
DOI: 10.1186/s12974-018-1172-y