Urine High-Sensitive Troponin T—Novel Biomarker of Myocardial Damage in Children

Background: The use of high-sensitive cardiac troponin T (hsTnT) in urine as a marker damage children has not yet been reported. Elimination troponins is dependent on renal function; persistently increased serum hsTnT concentrations were observed among individuals with impaired function. aim this study was to investigate and levels its correlation infants younger than 24 months age after surgery. Methods: This conducted 90 under who divided into three groups. experimental group consisted patients intracardiac surgery ventricular septal defect (VSD), first control extracardiac formation bidirectional cavopulmonary connection (BCPC), the second healthy children. Troponin values ​​were determined at five time points: sample taken day before (measure 0) other four samples surgery; immediately 1), 2), third 3), fifth postoperative 5). morning sampled for determining infants. Results: A positive between found. Urine measured preoperatively undergoing BCPC higher (median 7.3 [IQR 6.6–13.3] ng/L) compared VSD 6.5 4.4–8.9] well population 5.5 5.1–6.7] ng/L). After logarithmic transformation, there no statistically significant difference concentration groups any point measurement or postoperatively. Statistically negative found glomerular filtration rate estimated by creatinine clearance. Patients underwent surgical repair had significantly measurements those Conclusions: According results study, function appears have major effect urinary concentrations, we cannot conclude that an appropriate assessment myocardial Nevertheless, more research needed reach better understanding final elimination