URINARY STEROIDS OF CATS. 1. ABSENCE OF 17-OXO STEROIDS

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Urinary Steroids of Cats

Adrenal steroid secretion by cats has been studied by Bush (1951, 1953) and reviewed by Dorfman (1959). The cat adrenal secretes both cortisol and corticosterone. Arteta & Borrell (1958) and Borrell (1958) have reported studies of urinary excretion of 17-hydroxy corticosteroids (PorterSilber chromogens). Cats appear to excrete in urine very low concentrations of 17-hydroxy corticosteroids, all ...

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The analysis of urinary 17-oxo steroids by gradient elution.

The present work was initiated by the observation of Reifenstein, Homburger & Dobriner (1950) that 3a: 1 1l-dihydroxy-5p-androstan-17-one (1 l,B-hydroxyaetiocholanolone), a minor component of the urinary 17-oxo steroids, was significantly associated with neoplastic growth. The re-examination of this problem has led to the development of a micro method for the quantitative separation and determi...

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Oxidation of urinary 17-oxogenic steroids with sodium metaperiodate.

Oxidation of urinary pregnane-17,20-diols (17.oxogenic steroids) by sodium metaperiodate is complete within 10 mm at 55#{176}C if the concentration of sodium metaperiodate at the end of the reaction exceeds 1.5 X 10-SM. A safe excess of sodium metaperiodate is present if assay samples, after incubation for 10 mm at 55#{176}C in 3 X 10-EM ethylene glycol, give a positive test with starch-iodide ...

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Synthesis of Novel 17-Oxo-17a-Aza-D-Homo-3, 5-Seco-Steroids as Potential 5α-Reductase Inhibitors

Benign prostatic hyperplasia (BPH) is a non-malignant enlargement of the prostate gland. Itis a leading disorder of the elderly male population. Excessive production of dihydrotestosteronehas been implicated in this pathological condition. Steroidal 5α-reductase is a membrane boundNADPH dependent enzyme which is responsible for the conversion of testosterone (T) todihydrotestosterone (DHT). The...

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Urinary steroids. 1. Formation and determination of 3:5-dinitrobenzoates of alcoholic steroids.

Peters, J. P. & Van Slyke, D. D. (1931). Quantitative Clinical Chemistry, vol. 2. London: Bailliere, Tindall and Cox. Pfaltz, M. H. & Baudisch, 0. (1923). J. Amer. chem. Soc. 45, 2972. Rigg, T., Stein, G. & Weiss, J. (1952). Proc. Roy. Soc. A, 211, 375. Scholes, G., Stein, G. & Weiss, J. (1949). Nature, Lond., 164, 709. Scholes, G. & Weiss, J. (1950). Nature, Lond., 166, 640. Scholes, G. & Weis...

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ژورنال

عنوان ژورنال: Biochemical Journal

سال: 1963

ISSN: 0006-2936

DOI: 10.1042/bj0890051