Urinary Sediment miRNAs Reflect Tubulointerstitial Damage and Therapeutic Response in IgA Nephropathy
نویسندگان
چکیده
منابع مشابه
Urinary sediment miRNAs reflect tubulointerstitial damage and therapeutic response in IgA nephropathy
BACKGROUND Immunoglobulin A nephropathy (IgAN) is the most common glomerulonephritis worldwide. The clinical spectrum of IgAN varies from minor urinary abnormalities to rapidly progressive renal failure. Evaluation of the disease by repeated renal biopsy is not practical due to its invasive procedure. Urinary sediment miRNAs promise to serve as non-invasive biomarkers to assess kidney injury of...
متن کاملSelection of urinary sediment miRNAs as specific biomarkers of IgA nephropathy
The miRNAs in urinary sediment are easy to obtain, which provides a new approach to searching for non-invasive biomarkers of IgA nephropathy (IgAN). Compared with normal controls (n = 3), 214 different miRNAs in the urinary sediment of IgAN (n = 9) were found by miRNA chip assay. By quantitative PCR analysis, miR-25-3p, miR-144-3p and miR-486-5p were confirmed to be significantly higher in IgAN...
متن کاملExpression of MicroRNAs in the Urinary Sediment of Patients with IgA Nephropathy
BACKGROUND Micro-RNAs (miRNAs) regulate one-third of all protein-coding genes and are fundamental in the pathophysiology of a wide range of diseases. We studied the expression of several miRNA species (miR-200 family, miR-205 and miR-192) in the urinary sediment of patients with IgA nephropathy (IgAN). METHODS We studied 43 patients with biopsy-proven IgAN. Urinary expression of miRNAs was de...
متن کاملDoes circulating erythropoietin reflect progression of IgA nephropathy? Comparison with urinary N-acetyl-beta-D-glucosaminidase.
BACKGROUND Recent reports describe that erythropoietin (Epo) is produced by peritubular interstitial fibroblast-like cells in response to a hypoxic stimulus. We studied serum Epo levels as a possible marker of tubulointerstitial damage in the progression of IgA nephropathy (IgAN), in comparison with urinary (u-) levels of N-acetyl-beta-D-glucosaminidase (NAG), which is mainly derived from proxi...
متن کاملThe glomerular response to IgA deposition in IgA nephropathy.
Compelling evidence points to a role for IgA receptors in the pathogenesis of IgA nephropathy. The soluble form of the type I IgA receptor (FcalphaRI or CD89) forms complexes with IgA that can be found in patients' serum and that initiate the disease in CD89 transgenic mice. A nonclassic IgA receptor, identified as the transferrin receptor (TfR), is highly expressed in patients' mesangium and c...
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ژورنال
عنوان ژورنال: Hong Kong Journal of Nephrology
سال: 2015
ISSN: 1561-5413
DOI: 10.1016/j.hkjn.2015.08.094