Urinary excretion of aflatoxin M1 after administration of aflatoxin B1 in sucrose- or starch-rich diets
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چکیده
منابع مشابه
Excretion of Aflatoxin M1 in milk of goats fed diet contaminated by Aflatoxin B1
An experiment was carried out to study the excretion of aflatoxin M1(AFM1) in milk of three goats fed a single dose (0.8mg/head) of pure aflatoxin B1 (AFB1). The values of AFM1 concentration excreted in milk was highly variable among goats, even if the pattern of excretion over time was very similar among the three animals. AFM1 was first detected at the milking performed 1h after the AFB1 admi...
متن کاملCarcinogenicity of dietary aflatoxin M1 in male Fischer rats compared to aflatoxin B1.
Aflatoxin M1 (AFM), an hydroxy metabolite of the potent carcinogenic mycotoxin aflatoxin B1 (AFB) is frequently found in milk and other dairy products. Sufficient amounts of AFM were produced to study the carcinogenicity of this compound. AFM was fed to male Fischer rats starting at 7 weeks up to 21 months of age. Agar-based semisynthetic diets contained 0.0, 0.5, 5.0, and 50.0 micrograms/kg of...
متن کاملExcretion of an aflatoxin-guanine adduct in the urine of aflatoxin B1-treated rats.
Administration of aflatoxin B1 (AFB1) to rats resulted in the urinary excretion of 2,3-dihydro-2-(N7-guanyl)-3-hydroxyaflatoxin B1. This is the major product formed by the interaction in vivo of AFB1 with rat liver nucleic acids. The adduct was isolated from urine by the combined use of preparative and analytical high-pressure liquid chromatography and was quantitated by measurement of absorban...
متن کاملComparative binding and sequence interaction specificities of aflatoxin B1, aflatoxicol, aflatoxin M1, and aflatoxicol M1 with purified DNA.
The covalent binding of the activated forms of several aflatoxins to N-7 of guanine residues on purified DNA has been studied. The aflatoxins include aflatoxin B1 (AFB1) and two human metabolites, aflatoxicol and aflatoxin M1, along with aflatoxicol M1, a rabbit and trout metabolite. DNA binding studies using tritiated [3H]aflatoxins indicate that equimolar solutions of each aflatoxin upon acti...
متن کاملA Survey on Relationship between Diet and Urinary Excretion of Aflatoxin M1: A Screening Pilot Study on Iranian Population
Background: Aflatoxins are found in the most types of foods such as corn, peanuts, pistachio, rice, milk, and etc. These toxins may cause several adverse health effects, notably cancer. The main aim of this study was to evaluate excretion level of aflatoxin M1 (AFM1), as a biomarker of aflatoxin B1 exposure, in urine samples of Iranian population. Also, relationship between diet and urinary exc...
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ژورنال
عنوان ژورنال: British Journal of Nutrition
سال: 1978
ISSN: 0007-1145,1475-2662
DOI: 10.1079/bjn19780137