Uric acid and cardiovascular disease: A clinical review

Podagra, uric acid, and cardiovascular disease.

He should not have been. All too often, rigorous examination debunks conventional wisdom. Reassuringly, in this case, Drs Choi and Curhan found evidence to support long-standing belief. These dedicated and productive students of the pathogenesis and natural history of gout have here reported empiric data from the 51 000 male nonphysician health professionals who participated in the Health Profe...

Serum uric acid and cardiovascular disease.

Uric acid and cardiovascular risk.

Copyright © 2008 Massachusetts Medical Society. An association of gout with hypertension, diabetes, kidney disease, and cardiovascular disease has been observed since the late 19th century. Early investigators, such as Frederick Mahomed, Alexander Haig, and Nathan Smith Davis, hypothesized that uric acid might be a cause of hypertension or renal disease. In 1897, in his presidential address to ...

Uric acid concentrations and the mechanisms of cardiovascular disease.

from the combined effects of systolic blood pressure and serum cholesterol although higher in men than women, is not supported by any definite cause. We would like to offer the following suggestions. The use of hormone replacement therapy (HRT) in women in the age group 45–55 has become common. It is also well known that this therapy raises high density lipoprotein cholesterol levels and lowers...

A Review of Uric Acid, Crystal Deposition Disease, and Gout

There has been increased interest in gout in both academic and clinical practice settings. Several reasons may explain this. The prevalence of both hyperuricemia and gout has risen in the last decades in developed countries and therefore the burden of gout has increased. The association of hyperuricemia and gout with cardiovascular outcomes and the opportunity of further benefits of interventio...