Urea–N,N-dimethylacetamide (1/1)

Zebrafish sperm cryopreservation with N,N-dimethylacetamide.

High fecundity, rapid generation time, and external development of optically clear embryos make the zebrafish (Danio rerio) a convenient vertebrate model for genetic, developmental, and disease studies. Efficient sperm cryopreservation enhances the zebrafish model system by optimizing productive use of facility space, extending the reproductive lifetime of males, providing an alternative to liv...

N,N Dimethylacetamide a drug excipient that acts as bromodomain ligand for osteoporosis treatment

N,N-Dimethylacetamide (DMA) is a water-miscible solvent, FDA approved as excipient and therefore widely used as drug-delivery vehicle. As such, DMA should be devoid of any bioactivity. Here we report that DMA is epigenetically active since it binds bromodomains and inhibits osteoclastogenesis and inflammation. Moreover, DMA enhances bone regeneration in vivo. Therefore, our in vivo and in vitro...

Biological monitoring of occupational exposure to N,N-dimethylacetamide with identification of a new metabolite.

AIMS To study the concentration of N,N-dimethylacetamide (DMA) and its metabolite, N-methylacetamide (NMA), in urine of workers occupationally exposed to DMA in a factory producing synthetic acrylic fibres. METHODS During the first phase, 223 workers exposed to low environmental concentrations of DMA provided urine samples at the end of a work shift. High concentrations of the unmodified solv...

A New Synthesis of Cinnamic Acids from Aromatic Aldehydes and N,n-dimethylacetamide Hydrochloride

Thorough studies of organic chemistry have emphasized the important role of reactive solvents in some condensation reactions, such as ethynylation of carbonylic compounds. Some of the most widely used reactive solvents for these reactions are N,N-dialkylacetamides, among which N,N-dimethylacetamide is prominent due to its particular reactivity. This is the reason why it had been used not only a...

Dimethylacetamide a drug excipient that acts as bromodomain ligand for osteoporosis treatment