منابع مشابه
[Uptake of bleomycin by human brain tumors].
Bleomycin (BLM), discovered by Umezawa et al. (1966a, b) is a kind of cytostatic antibiotic complex produced by a strain of Streptomyces verticillus, and was found by Ichikawa et al. (1967, 1968) to be highly effective against human squamous cell carcinoma. These authors observed relatively high concentration of BLM in the skin after subcutaneous injection in mice, and suggested that the therap...
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Background: A method to track liver tumor motion signals from fluoroscopic images without any implanted gold fiducial markers was proposed in this study to overcome the adverse effects on precise tumor irradiation caused by respiratory movement. Materials and Methods: The method was based on the following idea: (i) Before treatment, a series of fluoroscopic images corresponding to different bre...
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The disaccharide moiety is responsible for the tumor cell targeting properties of bleomycin (BLM). While the aglycon (deglycobleomycin) mediates DNA cleavage in much the same fashion as bleomycin, it exhibits diminished cytotoxicity in comparison to BLM. These findings suggested that BLM might be modular in nature, composed of tumor-seeking and tumoricidal domains. To explore this possibility, ...
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In the investigation of suspected lung cancer bleomycin labelled with cobalt-57 and gallium-67 labelled with citrate are currently used to detect the primary tumour and to establish the presence of metastases in the lung hilum and mediastinum. A comparative study of these radio-pharmaceuticals was performed in 63 patients with proved lung cancer. 57Co-bleomycin showed the primary tumour in 58 p...
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Background: Dendritic cells (DCs) are professional antigen presenting cells (APCs), and there is considerable interest in their application as a cellular adjuvant for cancer immunotherapy. Previous studies indirectly demonstrated that DCs were able to take up tumor lysate (crude soluble tumor antigens) and also cross-present tumor associated antigens (TAA) which elicits anti-tumor immune respo...
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ژورنال
عنوان ژورنال: RADIOISOTOPES
سال: 1973
ISSN: 1884-4111,0033-8303
DOI: 10.3769/radioisotopes.22.6_310