Uptake and Utilization of Selenium from Selenoprotein P
نویسندگان
چکیده
منابع مشابه
Dietary selenium and selenoprotein function
Selenium is a trace mineral and an essential nutrient in the human diet. Selenium is found in soil and water and consequently enters the food chain through the root ways of plants and aquatic organisms. Some areas of the world are low in soil selenium resulting in a selenium deficient population and the appearance of an associated heart disease and bone disorders that can be corrected with diet...
متن کاملSelenoprotein P is the essential selenium transporter for bones.
Selenium (Se) plays an important role in bone physiology as best reflected by Kashin-Beck disease, an endemic Se-dependent osteoarthritis. Bone development is delayed in children with mutations in SECIS binding protein 2 (SBP2), a central factor for selenoprotein biosynthesis. Circulating selenoprotein P (SePP) is positively associated with bone turnover in humans, yet its function for bone hom...
متن کاملMore roles for selenoprotein P: local selenium storage and recycling protein in the brain.
How is the essential micronutrient, selenium (Se), transported in the serum and then donated to tissues? In this issue of the Biochemical Journal, Schweizer and colleagues demonstrate, using conditional and total mouse knockout models, that SePP (selenoprotein P) is the major transporter of Se in the serum. Moreover, in the sanctuary area of the brain, SePP was shown to play a hitherto unexpect...
متن کاملEffects of Different Rates of Selenium Fertilizer and Cow Manure on Selenium Uptake in Festuca arundinacea
One of the crucial elements for livestock and human nutrition is selenium and its deficiency or toxicity can harm human and livestock health. The present study is designed with the aim of studying the effect of different levels of selenium fertilizer (Selcote-Ultra) and cow manure on the uptake of selenium in tall fescue. For this purpose, a pot experiment with complete randomized block design ...
متن کاملAll regions of mouse brain are dependent on selenoprotein P for maintenance of selenium.
The brain and testis retain selenium better than other tissues during selenium deficiency. Studies of mice with selenoprotein P (Sepp1) deleted (Sepp1(-/-) mice) showed that brain and testis selenium levels are largely dependent on Sepp1. Therefore, we examined tissue selenium in mice fed varying amounts of selenium and in Sepp1(-/-) mice to characterize better the role(s) of Sepp1. Mice were f...
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ژورنال
عنوان ژورنال: Biological Trace Element Research
سال: 2017
ISSN: 0163-4984,1559-0720
DOI: 10.1007/s12011-017-1044-9