Upper reference limits for biomarkers of exposure to aromatic diisocyanates
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چکیده
منابع مشابه
Upper reference limits for biomarkers of exposure to aromatic diisocyanates.
OBJECTIVES The objectives of this study were to determine the levels of 2,4-toluenediamine, 2,6-toluenediamine, 1,5-naphthtalenediamine and 4,4'-methylenediphenyldianiline in hydrolyzed urine and plasma for occupationally unexposed workers and to calculate upper reference limits (URLs). These analytes are biomarkers of exposure to 2,4-toluene diisocyanate and 2,6-toluene diisocyanate (2,4-TDI a...
متن کاملProtein adducts as biomarkers of exposure to aromatic diisocyanates in workers manufacturing polyurethane (PUR) foam.
This work was undertaken to investigate the usefulness of diisocyanate-related protein adducts in blood samples as biomarkers of occupational exposure to toluene diisocyanate (TDI; 2,4- and 2,6-isomers) and 4,4'-methylenediphenyl diisocyanate (MDI). Quantification of adducts as toluene diamines (TDAs) and methylenedianiline (MDA) was performed on perfluoroacylated derivatives by gas chromatogra...
متن کاملBiomarkers of exposure in Monday morning urine samples as a long-term measure of exposure to aromatic diisocyanates.
PURPOSE Exposure to diisocyanates is a known occupational hazard. One method for monitoring occupational exposure is by analyzing biomarkers in hydrolyzed urine and plasma. The half-life of the biomarkers in plasma is about 3 weeks, and the urinary elimination is divided into one fast (hours) and one slow phases (weeks). Polymorphism in glutathione S-transferase enzymes (GST) is earlier shown t...
متن کاملDose-response modeling of occupational exposure to polycyclic aromatic hydrocarbons with biomarkers of exposure and effect.
In regulatory toxicology, the dose-response relationship between occupational exposure and biomarkers is of importance in setting threshold values. We analyzed the relationships between occupational exposure to polycyclic aromatic hydrocarbons (PAH) and various biomarkers of internal exposure and DNA damage with data from 284 highly exposed male workers. Personal exposure to phenanthrene and ot...
متن کاملOccupational exposure to diisocyanates in polyurethane foam factory workers.
OBJECTIVES The aim of the study was to evaluate health effects of occupational exposure to diisocyanates (DIC) among polyurethane foam products factory workers. MATERIAL AND METHODS Thirty workers had a physical examination, skin prick tests with common allergens, allergen-specific immunoglobulin E (IgE) antibodies to diisocyanates and pulmonary function tests. Concentrations of selected isoc...
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ژورنال
عنوان ژورنال: International Archives of Occupational and Environmental Health
سال: 2005
ISSN: 0340-0131,1432-1246
DOI: 10.1007/s00420-005-0619-5