Updated roles of cGAS-STING signaling in autoimmune diseases

Natural immunity, the first line for body to defense against invasion of pathogen, serves as body’s perception presence pathogens depends on nucleic acid recognition mechanisms. The cyclic GMP-AMP synthase-stimulator interferon gene (cGAS-STING) signaling pathway is considered an essential pattern and effector in natural immune system mainly responsible recognizing DNA molecules present cytoplasm activating downstream pathways generate type I interferons some other inflammatory factors. STING, a crucial junction protein innate system, exerts role host resistance external pathogen invasion. Also, with same character molecules, inseparable from response. In particular, when expression STING upregulated or its related are overactivated, may develop serious infectious disorders due generation excessive responses, non-infectious diseases, autoimmune diseases. recent years, accumulating studies indicated that abnormal activation cGAS-STING modulated by receptor cGAS closely associated development occurrence diseases (AID). Thereof, explore in-depth inflammation be helpful provide new avenues treatment these clinic. This article reviews process important roles, therapeutic drugs AID, aiming improve our understanding AID achieve better diagnosis AID.