Update on Gene Therapy as an Antineoplastic Alternative
نویسندگان
چکیده
منابع مشابه
Chloroquine enjoys a renaissance as an antineoplastic therapy
Chloroquine (CQ) and hydroxychloroquine (HCQ), oral lysosomotropic agents with well-studied toxicity profiles, and antimalarial and antirheumatic activity, have been repurposed as antineoplastic agents based on preclinical data showing efficacy in preinvasive cancer, cancer stem cells and metastatic cancer. Phase I/II clinical trials are providing safety and efficacy data regarding CQ or HCQ mo...
متن کاملRetroviral vectors and gene therapy: An update
Gene therapy aims at treatment of diseases by transfer of genetic material into specific cells of a patient. So the transduction of appropriate target cell is critical. Retroviruses infect nearly every cell in the target population and become integrated in host cell genome for a stable expression. All retroviruses have only three structural genes gag, pol and env, except for lentiviruses where ...
متن کاملApoE Gene Therapy: An Overview and Update
Atherosclerosis remains the leading cause of death in industrialized societies. Apolipoprotein E (ApoE) is an attractive candidate to treat hypercholesterolemia and coronary heart disease, as it is a circulating protein with pleiotropic atheroprotective actions. Here, we describe several "gene addition" approaches and on-going developments to achieve efficient delivery and long-term expression....
متن کاملAtracurium as an Alternative to Succinylcholine in Electroconvulsive Therapy: A Randomized Clinical Trial
Background: Electroconvulsive Therapy (ECT) is a successful treatment option for various psychiatric disorders. It is performed under general anesthesia where succinylcholine is the preferred muscle relaxant in this process. However its several contraindications and potential adverse effects, and the fact that it is not always available should be considered. Therefore, finding an effective and ...
متن کاملCryotherapy as an alternative therapy for the treatment of recalcitrant alopecia areata
Background: The cold-induced inflammation of cryotherapy mayalter the immunologic processes and structural components ofthe hair follicles responsible for AA. The aim of this study was tostudy the efficacy of cryotherapy in alopecia areata, and totalis.Method: Forty-four patients with recalcitrant scalp alopeciaareata or totalis were treated with cryotherapy. The cryo-systemchosen was a closed ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Open access journal of biomedical science
سال: 2021
ISSN: ['2690-487X']
DOI: https://doi.org/10.38125/oajbs.000271