Update on Angiotensin II Subtype 2 Receptor: Focus on Peptide and Nonpeptide Agonists

Angiotensin II (Ang II) is the most dominant effector component of renin-angiotensin system (RAS) that generally acts through binding to two main classes G protein–coupled receptors, namely Ang subtype 1 receptor (AT1R) and angiotensin 2 (AT2R). Despite some controversial reports, activation AT2R antagonizes effects on AT1R. Studying signaling, function, its specific ligands in cell culture or animal studies has confirmed beneficial throughout body. These characteristics classify as part protective arm RAS that, along with functions (1–7) Mas modulates harmful AT1R activated classic RAS. Although primary ligand for AT2R, we have summarized other natural synthetic peptide nonpeptide agonists critical evaluation their structure, mechanism action, biologic activity. SIGNIFICANCE STATEMENT one components a significant prospective mediating action body9s homeostasis. Targeting offers substantial clinical application possibilities modulating various pathological conditions. This review provided concise information regarding potential applications diseases.