منابع مشابه
MMP-3 as a predictor for structural remission in RA patients treated with MTX monotherapy
BACKGROUND The study was undertaken to assess the efficacy of methotrexate (MTX) monotherapy on the radiographic progression of individual rheumatoid arthritis (RA) patients, each of whom had received MTX monotherapy for 3 years with an option to change to biological disease-modifying anti-rheumatic drugs (bDMARDs). We also looked for predictors of radiographic non-progression in these patients...
متن کاملBioavailability of higher dose MTX comparing oral and subcutaneous administration in patients with RA.
3. Information on permissions/orders of reprints rheumatology and related fields. Silverman featuring research articles on clinical subjects from scientists working in is a monthly international serial edited by Earl D.
متن کاملMethotrexate (MTX) and albumin coupled with MTX (MTX-HSA) suppress synovial fibroblast invasion and cartilage degradation in vivo.
OBJECTIVE To investigate the effect of methotrexate (MTX) and albumin coupled with methotrexate (MTX-HSA) on cartilage invasion and induction of perichondrocytic degradation by rheumatoid arthritis synovial fibroblasts (RA SF) in vivo. METHODS Human cartilage and RA SF were co-transplanted in three groups of severe combined immunodeficient mice (SCID), which received 1 mg/kg free MTX (n = 9),...
متن کاملIdentification of 7 Proteins in Sera of RA Patients with Potential to Predict ETA/MTX Treatment Response
OBJECTIVE The recent growth of innovating biologics has opened fascinating avenues for the management of patients. In rheumatoid arthritis, many biologics are currently available, the choice of which being mostly determined empirically. Importantly, a given biologic may not be active in a fraction of patients and may even provoke side effects. Here, we conducted a comparative proteomics study i...
متن کاملPolymorphisms within the adenosine receptor 2a gene are associated with adverse events in RA patients treated with MTX
OBJECTIVE To examine the role of adenosine receptor 2a gene (ADORA2a) polymorphisms on outcome of MTX treatment in RA. METHODS Subjects included 309 RA patients with a defined response to MTX. Patients were included if they were (i) good responders (n = 147) (ESR <20 for >6/12 on stable dose of MTX) (ii) inefficacy failures (n = 101) (physician statement and failure to reduce ESR/CRP by 20%) ...
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ژورنال
عنوان ژورنال: Nature Reviews Rheumatology
سال: 2020
ISSN: 1759-4790,1759-4804
DOI: 10.1038/s41584-020-0479-0