Unusually high conservation of untranslated sequences in cDNAs for Trimeresurus flavoviridis phospholipase A2 isozymes.
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چکیده
منابع مشابه
The Finding of a Group IIE Phospholipase A2 Gene in a Specified Segment of Protobothrops flavoviridis Genome and Its Possible Evolutionary Relationship to Group IIA Phospholipase A2 Genes
The genes encoding group IIE phospholipase A2, abbreviated as IIE PLA2, and its 5' and 3' flanking regions of Crotalinae snakes such as Protobothrops flavoviridis, P. tokarensis, P. elegans, and Ovophis okinavensis, were found and sequenced. The genes consisted of four exons and three introns and coded for 22 or 24 amino acid residues of the signal peptides and 134 amino acid residues of the ma...
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A mixed toxoid consisting of HR1 and HR2 toxoids derived from Habu (Trimeresurus flavoviridis) venom was examined for immunogenicity in guinea pigs, rabbits, monkeys and human beings. The toxoid produced both anti-HR1 and anti-HR2 in various animals. The immunogenicity of the toxoid was superior to a crude toxoid in both guinea pigs and monkeys. Immunized monkeys showing circulating antitoxin p...
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Angiotensin II in proximal tubule epithelium is known to stimulate the release of arachidonic acid after stimulation of phospholipase A2 (PLA2) independent of phospholipase C-mediated signaling. Furthermore, an angiotensin II type 2 receptor subtype has been linked to this signaling cascade. We investigated the regulation and differential stimulation of PLA2s by comparing the PLA2 activities as...
متن کاملBiological and Pathological Studies of Rosmarinic Acid as an Inhibitor of Hemorrhagic Trimeresurus flavoviridis (habu) Venom
In our previous report, rosmarinic acid (RA) was revealed to be an antidote active compound in Argusia argentea (family: Boraginaceae). The plant is locally used in Okinawa in Japan as an antidote for poisoning from snake venom, Trimeresurus flavoviridis (habu). This article presents mechanistic evidence of RA's neutralization of the hemorrhagic effects of snake venom. Anti-hemorrhagic activity...
متن کاملCentral response to infra-red stimulation of the pit receptors in a crotaline snake, Trimeresurus flavoviridis.
The snake family Viperidae is divided into two subfamilies by the presence or absence of pit receptors. The Viperinae, found throughout Europe, Africa and Asia, apparently lack any form of infra-red receptor (Bullock & Barrett, 1968). The Crotalinae, instead, are characterized by the presence of a highly specialized pit receptor in the loreal region of either side of the face. Five principal ge...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1992
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.89.18.8557