Unsolved challenges in diuretic therapy for acute heart failure: a focus on diuretic response
نویسندگان
چکیده
منابع مشابه
Combined aquaretic and diuretic therapy in acute heart failure
INTRODUCTION Acute heart failure (AHF) is a leading cause of hospitalization and readmission in the US. The present study evaluated maximum diuresis while minimizing electrolyte imbalances, hemodynamic instability, and kidney dysfunction, to achieve a euvolemic state safely in a shorter period of time. METHODS AND RESULTS A protocol of combined therapy with furosemide, metolazone, and spirono...
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BACKGROUND Rather than the absolute dose of diuretic or urine output, the primary signal of interest when evaluating diuretic responsiveness is the efficiency with which the kidneys can produce urine after a given dose of diuretic. As a result, we hypothesized that a metric of diuretic efficiency (DE) would capture distinct prognostic information beyond that of raw fluid output or diuretic dose...
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s 40 venous capacitance within a few minutes before any with oedema is defined as a clinical state where the braking phenomenon occurs before the therapeutic measurable increase in urinary output can be seen [1,2]. This rapid haemodynamic improvement is goal is reached. thought to be due to the release of vasodilatory prostaglandins [3]. However, in a study in patients with severe oedema, i.v. ...
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heart failure (hf) is still a major problem worldwide with high morbidity and mortality rates. the recently developed medication for hf is still incapable of reducing its morbidity and mortality, and clinical data supporting the efficacy and safety of its mainstay therapy remain insufficient. arginine-vasopressin (avp) plays important roles in circulatory and water homeostasis, one of which is ...
متن کاملDiuretic strategies in patients with acute decompensated heart failure.
BACKGROUND Loop diuretics are an essential component of therapy for patients with acute decompensated heart failure, but there are few prospective data to guide their use. METHODS In a prospective, double-blind, randomized trial, we assigned 308 patients with acute decompensated heart failure to receive furosemide administered intravenously by means of either a bolus every 12 hours or continu...
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ژورنال
عنوان ژورنال: Expert Review of Cardiovascular Therapy
سال: 2015
ISSN: 1477-9072,1744-8344
DOI: 10.1586/14779072.2015.1087313