Unsaturated Fatty Acids Disrupt Smad Signaling in Gonadotrope Cells Leading to Inhibition of FSHβ Gene Expression
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منابع مشابه
Fatty acid desaturation in lung: inhibition by unsaturated fatty acids.
The activity of the enzyme system involved in desaturation of palmitic and stearic acid has been examined in lungs of rats fed fat-free diets supplemented either with 4% safflower oil (controls) or 4% tripalmitin (essential fatty acid (EFA) deficient) both in vivo and in vitro in lung slices. Desaturation, as measured by appearance of 14C-labeled monounsaturated fatty acid in pulmonary total li...
متن کاملUnsaturated fatty acids.
There is good scientific evidence that dietary fatty acid composition is involved in the aetiology of many diseases. Increasing the supply of n-3 polyunsaturated fatty acids (PUFA) may reduce the risk of CHD. Several scientific organizations (for example, see Department of Health, 1991, 1994; British Nutrition Foundation, 1992; Scientific Committee for Food, 1993; Food and Agriculture Organizat...
متن کاملInhibition of platelet function by cis-unsaturated fatty acids.
The uptake of free fatty acids has previously been shown to affect the capping of lymphocytes, and there is evidence that different types of fatty acids may partition into separate lipid domains in cell surface membranes. In studies of gel-filtered human platelets, we found that cis-unsaturated fatty acids (1-35 microM) inhibited platelet shape change, aggregation, and secretion of 5-hydroxytry...
متن کاملUnsaturated fatty acids in microorganisms.
Reports from this laboratory have described the existence of two different pathways for the biosynthesis of long chain monounsaturated fatty acids by microorganisms. In yeast, oleic and palmitoleic acids are formed oxidatively from the corresponding saturated acids by processes requiring molecular oxygen and TPNH (1). The same conversions have been demonstrated in AWycobacterium phlei (2), in t...
متن کاملHydroformylation of Unsaturated Fatty Acids
When hydroformylation of unsaturated fatty materials is done with rhodiu~-tripheny:lphosphine (or phosphite) catalysts, a number of advantages become apparent compared to cobalt carbonyl-catalyzed reactions. With rhodium, the reaction can be carried out (a) at pressures as low as 200 psi, (b) at each double bond location in a polyunsaturated fatty acid, and (c) in high yield and conversion. Sol...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 2014
ISSN: 0013-7227,1945-7170
DOI: 10.1210/en.2013-1833