Unrelated donor stem cell transplantation for transfusion-dependent thalassemia
نویسندگان
چکیده
منابع مشابه
Hematopoietic Stem Cell Transplantation for Thalassemia
Thalassemia is an autosomal recessive disorder associated with defective synthesis of the α- or β-chain of hemoglobin. For β-thalassemia major patients, therapeutic options are either monthly red cell transfusions and chelation therapy or allogeneic stem cell transplant. Stem cell transplant is the only curative approach and success is inversely correlated with the degree of iron overload and h...
متن کاملOutcomes from unrelated donor hematopoietic stem cell transplantation.
BACKGROUND Allogeneic hematopoietic cell transplantation (HCT) offers a curative treatment option for management of a variety of hematologic malignancies. While sibling donors have been the gold standard for adult patients in need of an HCT, not all patients have a suitable family donor. The availability of unrelated volunteer donor registries and alternative stem cell sources has expanded the ...
متن کاملUnrelated donor haemopoietic stem-cell transplantation: ATG or not?
Chronic graft-versus-host disease (GVHD) is a multisystemic syndrome involving tissue inflammation and fibrosis that shares many clinical manifestations with autoimmune diseases such as systemic lupus erythematous or systemic sclerosis. Despite being associated with lower relapse rates, chronic GVHD is the main cause of late mortality after unrelated allogeneic haemopoietic stem-cell transplant...
متن کاملhematopoietic stem cell transplantation for thalassemia
thalassemia is an autosomal recessive disorder associated with defective synthesis of the α- or β-chain of hemoglobin. for β-thalassemia major patients, therapeutic options are either monthly red cell transfusions and chelation therapy or allogeneic stem cell transplant. stem cell transplant is the only curative approach and success is inversely correlated with the degree of iron overload and h...
متن کاملA novel conditioning regimen improves outcomes in β-thalassemia major patients using unrelated donor peripheral blood stem cell transplantation.
We used a novel NF-08-TM transplant protocol based on intravenous busulfan, cyclophosphamide, fludarabine, and thiotepa in 82 consecutive patients with β-thalassemia major (TM), including 52 with allogeneic peripheral blood stem cell transplantation (PBSCT) from unrelated donors (UDs) with well-matched human leukocyte antigens and 30 with hematopoietic stem cell transplantation (HSCT) from matc...
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ژورنال
عنوان ژورنال: Annals of the New York Academy of Sciences
سال: 2016
ISSN: 0077-8923
DOI: 10.1111/nyas.13019