Unraveling the Deleterious Effects of Cancer-Driven STK11 Mutants through Conformational Sampling Approach
نویسندگان
چکیده
منابع مشابه
Unraveling the Deleterious Effects of Cancer-Driven STK11 Mutants Through Conformational Sampling Approach
Tumor suppressor gene, STK11, encodes for serine-threonine kinase, which has a critical role in regulating cell growth and apoptosis. Mutations of the same lead to the inactivation of STK11, which eventually causes different types of cancer. In this study, we focused on identifying those driver mutations through analyzing structural variations of mutants, viz., D194N, E199K, L160P, and Y49D. Na...
متن کاملthe effect of functional/notional approach on the proficiency level of efl learners and its evaluation through functional test
in fact, this study focused on the following questions: 1. is there any difference between the effect of functional/notional approach and the structural approaches to language teaching on the proficiency test of efl learners? 2. can a rather innovative language test referred to as "functional test" ge devised so so to measure the proficiency test of efl learners, and thus be as much reliable an...
15 صفحه اولthe use of appropriate madm model for ranking the vendors of mci equipments using fuzzy approach
abstract nowadays, the science of decision making has been paid to more attention due to the complexity of the problems of suppliers selection. as known, one of the efficient tools in economic and human resources development is the extension of communication networks in developing countries. so, the proper selection of suppliers of tc equipments is of concern very much. in this study, a ...
15 صفحه اولAccelerating Protein Conformational Sampling Using Multiscale Approach
Searching conformational ensembles of proteins remains a challenge in atomistic simulation of biomolecules. One approach to accelerate the protein sampling is to take advantage of rough energy surface from the coarse-grained model and, at the same time, to persist atomistic details from the all-atom model. Multiscale enhanced sampling (MSES) of all atoms and topology-based coarse-grained replic...
متن کاملthe effect of a selfregulatory approach on the improvement of efl learners listening comprehension
تاثیر آموزش مهارت خود محوری بر روی ارتقاء مهارت شنیداری زبان آموزان هدف این پژوهش بررسی عوامل موثر در ارتقا مهارت شنیداری زبان آموزان ایرانی بود. در مرحله اول این تحقیق پژوهشگر پس از انجام مصاحبه نود زبان آموز را با استفاده از تست ایلتس انتخاب شدند. برای بررسی عوامل عوامل موثر در ارتقا مهارت شنیداری زبان آموزان ایرانی از دو نوع فیلم ویرایش شده و ویرایش نشده استفاده گردید.برای انجام تح...
ذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cancer Informatics
سال: 2016
ISSN: 1176-9351,1176-9351
DOI: 10.4137/cin.s38044