Unraveling determinants of transcription factor binding outside the core binding site
نویسندگان
چکیده
منابع مشابه
Unraveling determinants of transcription factor binding outside the core binding site.
Binding of transcription factors (TFs) to regulatory sequences is a pivotal step in the control of gene expression. Despite many advances in the characterization of sequence motifs recognized by TFs, our ability to quantitatively predict TF binding to different regulatory sequences is still limited. Here, we present a novel experimental assay termed BunDLE-seq that provides quantitative measure...
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MOTIVATION The automatic identification of over-represented motifs present in a collection of sequences continues to be a challenging problem in computational biology. In this paper, we propose a self-organizing map of position weight matrices as an alternative method for motif discovery. The advantage of this approach is that it can be used to simultaneously characterize every feature present ...
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ژورنال
عنوان ژورنال: Genome Research
سال: 2015
ISSN: 1088-9051,1549-5469
DOI: 10.1101/gr.185033.114