Unlike p53, p27 failed to exhibit an anti-tumor genetic interaction with Ku80
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چکیده
منابع مشابه
Drosophila UTX Coordinates with p53 to Regulate ku80 Expression in Response to DNA Damage
UTX is known as a general factor that activates gene transcription during development. Here, we demonstrate an additional essential role of UTX in the DNA damage response, in which it upregulates the expression of ku80 in Drosophila, both in cultured cells and in third instar larvae. We further showed that UTX mediates the expression of ku80 by the demethylation of H3K27me3 at the ku80 promoter...
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To enhance the penetration of P53 into tumor cells by fusion it with the cell penetrating peptide 9R. The fusion gene of 9R-p53 was cloned into the expression vector. The fusion protein, CPPs-P53, was expressed and purified. We detected the rate of cell growth inhibition and apoptosis by MTT and Annexin-V-FITC/PI double stained method respectively for measuring its effect on tumor cells. CPPs-P...
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p53, a tumor suppressor and a transcription factor, binds DNA in a sequence-specific manner. In more than half of human cancers, p53 has been found to be mutated with the loss of DNA-binding ability. In this review, we focus on the sensitive detection of interaction of tumor suppressor p53 with double-stranded DNA bearing the consensus sequence and proteins, such as monoclonal antibodies recogn...
متن کاملAlterations of tumor suppressor genes (Rb, p16, p27 and p53) and an increased FDG uptake in lung cancer.
OBJECTIVE The FDG uptake in lung cancer is considered to reflect the degree of malignancy, while alterations of some tumor suppressor genes are considered to be related to the malignant biological behavior of tumors. The aim of this study is to examine the relationship between FDG-PET and alterations in the tumor suppression genes of lung cancer. METHODS We examined 28 patients with primary l...
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The general overexpression of p53 by different types of tumor cells suggests that p53 immunity might be generally useful for tumor ininiunotherapy. We describe here the induction of immunity to p53 and resistance to tumor metastasis using an idiotypic network. Mice were immunized with domain-specific anti-p53 monoclonal antibodies (Abl): PAb-248 directed to the N-terminus; PAb-246 directed to t...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2009
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.8.15.9249