Universal antidote for aptamers

Antidote-controlled platelet inhibition targeting von Willebrand factor with aptamers.

Thrombus formation is initiated by platelets and leads to cardiovascular, cerebrovascular, and peripheral vascular disease, the leading causes of morbidity and mortality in the Western world. A number of antiplatelet drugs have improved clinical outcomes for thrombosis patients. However, their expanded use, especially in surgery, is limited by hemorrhage. Here, we describe an antiplatelet agent...

Activated charcoal for pediatric poisonings: the universal antidote?

PURPOSE OF REVIEW For decades, activated charcoal has been used as a 'universal antidote' for the majority of poisons because of its ability to prevent the absorption of most toxic agents from the gastrointestinal tract and enhance the elimination of some agents already absorbed. This manuscript will review the history of activated charcoal, its indications, contraindications, and the complicat...

Mani and shapur a universal faith for e universal kingdom

Humor: an antidote for stress.

Humor and laughter can be effective self-care tools to cope with stress. An ability to find humor gives us a sense of perspective on our problems. Laughter provides a physical release for accumulated tension. The article reviews research on the effect of humor and laughter on our immune function and resilience to stress. Resources for finding humor are included.

Receptor-based antidote for diphtheria.

Although equine diphtheria antitoxin may be an effective therapy for human diphtheria, its use often induces serum sickness. We describe here a strategy for developing an alternative treatment based on the human diphtheria toxin (DT) receptor/heparin-binding epidermal growth factor-like growth factor (HB-EGF) precursor. Recombinant mature human HB-EGF acts as a soluble receptor analog, binding ...