Unfractionated heparin monitoring with activated partial thromboplastin time
نویسندگان
چکیده
منابع مشابه
Activated partial thromboplastin time versus antifactor Xa heparin assay in monitoring unfractionated heparin by continuous intravenous infusion.
BACKGROUND Unfractionated heparin (UFH) has been used clinically for 5 decades. Despite being a cornerstone of anticoagulation, UFH is limited by its unpredictable pharmacokinetic profile, which makes close laboratory monitoring necessary. The most common methods for monitoring UFH are the activated partial thromboplastin time (aPTT) and antifactor Xa heparin assay (anti-Xa HA), but both presen...
متن کاملConcordance between Activated Partial Thromboplastin Time and Antifactor Xa Assay for Monitoring Unfractionated Heparin in Hospitalized Hyperbilirubinemic Patients.
BACKGROUND Activated partial thromboplastin time (aPTT) and antifactor Xa (anti-Xa) monitoring methods for unfractionated heparin (UFH) often disagree. The extent of discordance for those with elevated bilirubin remains unclear. Our objective was to evaluate concordance between activated aPTT and anti-Xa methods for hyperbilirubinemic patients on UFH. METHODS This was a retrospective cohort s...
متن کاملInterlaboratory agreement in the monitoring of unfractionated heparin using the anti-factor Xa-correlated activated partial thromboplastin time.
BACKGROUND In an effort to improve interlaboratory agreement in the monitoring of unfractionated heparin (UFH), the College of American Pathologists (CAP) recommends that the therapeutic range of the activated partial thromboplastin time (APTT) be defined in each laboratory through correlation with a direct measure of heparin activity such as the factor Xa inhibition assay. Whether and to what ...
متن کاملActivated partial thromboplastin time monitoring in patients receiving unfractionated heparin for venous thromboembolism in relation to clinical outcomes.
Venous thromboembolism (VTE) is a prevalent and serious condition, which requires anticoagulation treatment for prolonged time duration. The use of unfractionated heparin administered intravenously or subcutaneously for acute management of VTE has been studied with favourable clinical results. Most physicians use activated partial thromboplastin time to monitor the treatment effect, in an effor...
متن کاملBedside heparin monitoring by activated partial thromboplastin time measured with a dry reagent.
Activated partial thromboplastin time (APTT; also coagulation surface induced time [ID is a routine method for monitoring heparin treatment [2-5]. This time is influenced by the type of reagent, the method of analysis, and the laboratory instrument used; thus, the result will vary from one laboratory to another [6, 7]. Variation in heparin sensitivity between batches of re-agents produced from ...
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ژورنال
عنوان ژورنال: Pathology
سال: 2020
ISSN: 0031-3025
DOI: 10.1016/j.pathol.2020.01.138