Understanding the Intricacies of Iron Overload Associated with β-Thalassemia: A Comprehensive Review

β-thalassemia, a congenital genetic hematological disorder characterized by the decrease or absence of β-globin chains, leads to in levels Hemoglobin A. The affected individuals can be categorized into two cohorts based on transfusion dependency: transfusion-dependent thalassemia (TDT) and non-transfusion-dependent (NTDT). Remarkably, despite primary pathology lying chain depletion, β-thalassemia also exhibits an intriguing association with iron overload. Iron metabolism, tightly regulated physiological process, reveals complex interplay these patients. Over time, both β-thalassemic develop overload, albeit through distinct mechanisms. Addressing diverse complications that arise due overload patients, utilization chelators has gained lot significance. With varying efficacies, routes administration, modes action, different offer unique benefits In Indian context, three commercialized have emerged, showcasing high adherence rate chelator-based treatment regimens among individuals. this review, we explore connection between shedding light intricate mechanisms at play. We delve intricacies unveiling pathways leading accumulation Additionally, therapeutic efficacy managing is mentioned briefly, along guidelines for their usage India. Through comprehensive analysis, aim deepen our understanding paving way optimized strategies. Ultimately, findings provide valuable insights improving care outcomes β-thalassemia.