منابع مشابه
Reward processing by the opioid system in the brain.
The opioid system consists of three receptors, mu, delta, and kappa, which are activated by endogenous opioid peptides processed from three protein precursors, proopiomelanocortin, proenkephalin, and prodynorphin. Opioid receptors are recruited in response to natural rewarding stimuli and drugs of abuse, and both endogenous opioids and their receptors are modified as addiction develops. Mechani...
متن کاملBaseline reward circuitry activity and trait reward responsiveness predict expression of opioid analgesia in healthy subjects.
Variability in opioid analgesia has been attributed to many factors. For example, genetic variability of the μ-opioid receptor (MOR)-encoding gene introduces variability in MOR function and endogenous opioid neurotransmission. Emerging evidence suggests that personality trait related to the experience of reward is linked to endogenous opioid neurotransmission. We hypothesized that opioid-induce...
متن کاملOpioid receptor PET reveals the psychobiologic correlates of reward processing.
UNLABELLED Little is known about the neurobiologic correlates of human personality. On the basis of the key role of the central opioidergic system in addiction and substance abuse, we investigated the relationship between certain personality traits that are supposed to be relevant in addiction and the opioid receptor status in healthy subjects. METHODS We investigated 23 healthy male voluntee...
متن کاملOpioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward.
This review will introduce the concept of toll-like receptor (TLR)-mediated glial activation as central to all of the following: neuropathic pain, compromised acute opioid analgesia, and unwanted opioid side effects (tolerance, dependence, and reward). Attenuation of glial activation has previously been demonstrated both to alleviate exaggerated pain states induced by experimental pain models a...
متن کاملReward Processing by the Opioid System in the Brain
A. The endogenous opioid system and natural reinforcement 1383 B. The endogenous opioid system and drugs of abuse 1387 C. Perspectives: extending studies to animal models of drug addiction 1393 IV. Genetic Manipulation of the Opioid System, Reinforcement, and Drug Dependence 1393 A. Opioid receptor knockout mice 1393 B. Opioid peptide knockout mice 1394 C. Conclusion 1395 D. Perspectives: towar...
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ژورنال
عنوان ژورنال: Trends in Neurosciences
سال: 2015
ISSN: 0166-2236
DOI: 10.1016/j.tins.2015.01.002