Understanding biofilm formation in intravascular device-related infections

Biofilm Formation, Antimicrobial Resistance and Biofilm-Related Genes among Uropathogens Isolated from Catheterized Uro-Oncology Patients

Background and Objective: Despite the critical importance of catheter as an indwelling medical device, its prolonged utilization in hospitalized patients may lead to infection. This study aimed to identify distribution of uropathogenic bacteria isolated from catheterized uro-oncology patients, their biofilm production, and antimicrobial resistance patterns to generally -used antibiotics. Mater...

Association between methicillin susceptibility and biofilm regulation in Staphylococcus aureus isolates from device-related infections.

Production of icaADBC-encoded polysaccharide intercellular adhesin, or poly-N-acetylglucosamine (PIA/PNAG), represents an important biofilm mechanism in staphylococci. We previously described a glucose-induced, ica-independent biofilm mechanism in four methicillin-resistant Staphylococcus aureus (MRSA) isolates. Here, biofilm regulation by NaCl and glucose was characterized in 114 MRSA and 98 m...

Prevention of intravascular catheter-related infections.

PURPOSE To review the literature on prevention of intravascular catheter-related infections. DATA SOURCES The MEDLINE database, conference proceedings, and bibliographies of review articles and book chapters were searched for relevant articles. Primary authors were contacted directly if data were incomplete. STUDY SELECTION Studies met the following criteria unless otherwise stated: Trials ...

Management of intravascular catheter-related infections.

Prevention of intravascular catheter-related bloodstream infections.

solution available in clinical settings, especially when current Centers for Disease Control and Prevention guidelines state that only solutions of PPD containing 5 TU/0.1 mL should be used.1 We have discontinued the 250 TU formulation in our institution. We urge caution in the interpretation of tuberculin tests and suggest careful examination of the strength of the solution before administration.