Understanding and Preventing (N-Nitrosodimethylamine) NDMA Contamination of Medications
نویسندگان
چکیده
منابع مشابه
N-Nitrosodimethylamine (NDMA) as a Drinking Water Contaminant: A Review
N-Nitrosodimethylamine (NDMA) is a member of a family of extremely potent carcinogens, the N-nitrosamines. Until recently, concerns about NDMA mainly focused on the presence of NDMA in food, consumer products, and polluted air. However, current concern focuses on NDMA as a drinking water contaminant resulting from reactions occurring during chlorination or via direct industrial contamination. B...
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The water contaminant N-nitrosodimethylamine (NDMA) is a probable human carcinogen whose appearance in the environment is related to the release of rocket fuel and to chlorine-based disinfection of water and wastewater. Although this compound has been shown to be biodegradable, there is minimal information about the organisms capable of this degradation, and little is understood of the mechanis...
متن کاملPotential enhanced N-nitrosodimethylamine (NDMA) formation under water treatment conditions
This study investigates two aspects of NDMA formation reactions: (i) evaluation of the potential effect of formaldehyde on NDMA formation, particularly in reactions of dimethylamine (DMA) and nitrite, and (ii) assessment of potential NDMA formation from a range of polymeric coagulants and flocculants upon exposure to disinfection oxidants. The results show that the presence of formaldehyde can ...
متن کاملThe Effect of N-nitrosodimethylamine (NDMA) on Bax and Mcl-1 Expression in Human Neutrophils
In the present study we examined a role of pro-apoptotic Bax and anti-apoptotic Mcl-1 proteins, participating in the regulation of intrinsic apoptosis pathway in human neutrophils (PMNs) exposed to N-nitrosodimethylamine (NDMA), the environmental xenobiotic. For the purpose comparison, the same studies were conducted in autologous peripheral blood mononuclear cells (PBMCs). The production of cy...
متن کاملLeaching risk of N-nitrosodimethylamine (NDMA) in soil receiving reclaimed wastewater.
N-nitrosodimethylamine (NDMA) is a potential carcinogen frequently found in treated wastewater as a byproduct of chlorination. The potential for NDMA to contaminate the groundwater is a significant concern. A solute fate and transport model, Hydrus-1D, was used to evaluate the leaching potential of NDMA under different irrigation practices and soil properties. The results indicate that the risk...
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ژورنال
عنوان ژورنال: Annals of Pharmacotherapy
سال: 2019
ISSN: 1060-0280,1542-6270
DOI: 10.1177/1060028019892222