Uncovering Modern Clinical Applications of Fuzi and Fuzi-Based Formulas: A Nationwide Descriptive Study With Market Basket Analysis

Background: As time evolved, traditional Chinese medicine (TCM) became integrated into the global medical system as complementary treatments. Some essential TCM herbs started to play a limited role in clinical practices because of Western medication development. For example, Fuzi (Aconiti Lateralis Radix Praeparata) is toxic but indispensable herb. was mainly used poor circulation and life-threatening conditions by history records. However, with various options for treating critical currently, how clinically its indications modern are unclear. This study aimed evaluate Fuzi-based formulas using artificial intelligence data mining methods. Methods: nationwide descriptive market basket analysis cohort selected from Taiwan National Health Insurance database that contained one million national representatives between 2003 2010 our analysis. Descriptive statistics were performed demonstrate Fuzi. Market calculated Apriori algorithm discover association rules other herbs. Results: A total 104,281 patients 405,837 prescriptions identified. doctors found use pulmonary (21.5%), gastrointestinal (17.3%), rheumatologic (11.0%) diseases, not commonly cardiovascular diseases (7.4%). Long-term users often had following comorbidities diagnosed doctors: osteoarthritis (31.0%), peptic ulcers (29.5%), hypertension (19.9%), COPD (19.7%). Patients also concurrent medications such H2-receptor antagonists, nonsteroidal anti-inflammatory drugs, β-blockers, calcium channel blockers, aspirin. Through analysis, first time, we noticed many practical Fuzi-related herbal pairs Fuzi–Hsihsin (Asari et Rhizoma)–Dahuang (Rhei Rhizoma) neurologic headache. Conclusion: big applied uncover addition use. We provided necessary evidence on scientific current practices, discovered this helpful development new botanical drugs.