UNCONSCIOUSNESS ASSOCIATED WITH MIDAZOLAM AND ERYTHROMYCIN
نویسندگان
چکیده
منابع مشابه
Unconsciousness associated with midazolam and erythromycin.
An 8-yr-old boy suffering from an asymptomatic ventricular septal defect was given erythromycin for antibiotic prophylaxis before adenoidectomy. Sixty minutes after premedication with oral midazolam 0.5 mg kg-1 and oral atropine 0.03 mg kg-1, an infusion of erythromycin 400 mg was started. When 200 mg of erythromycin had been infused, the patient lost consciousness, but other vital functions re...
متن کاملThe erythromycin breath test predicts the clearance of midazolam.
Midazolam, a commonly used sedative and amnestic medication, has recently been shown to be largely metabolized in the liver by a cytochrome P450, termed CYP3A4. There is at least a tenfold intersubject variability in the liver content and catalytic activity of CYP3A4, which may in part account for the known interpatient differences in the kinetics of midazolam. To test this hypothesis, we deter...
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Objective—An emerging paradigm for understanding how anesthetics induce altered arousal is relating receptor targeting in specific neural circuits to electroencephalogram (EEG) activity. We have previously found that enhanced gamma amino-butyric acid A (GABAA) inhibitory postsynaptic currents (IPSCs) manifest with large-amplitude slow (0.1–1 Hz) and frontally coherent alpha (8–12 Hz) oscillatio...
متن کاملParoxysmal tachycardia with episodic unconsciousness.
Unconsciousness due to disturbed cardiac output is seen most often as a result of acquired heart block with unstable ventricular rhythm. Less often it occurs as a result of an arrhythmia which may appear to be primary or else be associated with some obvious cardiac disease. Although unconsciousness due to this cause is relatively uncommon, it is important that the basic condition be recognized....
متن کاملProlonged sedation related to erythromycin and midazolam interaction: a word of caution.
A 6 year old, 24 kg boy was referred for do an outpatient magnetic resonance imaging of the pelvis and femur as he was suffering with fever and progressive pain in hip area and limping. The boy was otherwise healthy, with an unremarkable medical history and review of systems. He was taking some medicines for fever, and the details were not known. As he was having a fear of injection, oral midaz...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1990
ISSN: 0007-0912
DOI: 10.1093/bja/65.6.826