Ultrastructural studies on mitochondrial swelling
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چکیده
منابع مشابه
Ultrastructural studies on mitochondrial swelling.
Mitochondrial swelling induced by valinomycin, calcium chloride and P(i) was studied after potassium permanganate fixation in suspension. Valinomycin induces a rapid K(+) influx, increase of the matrix space and out-folding of the cristae, with good preservation of the matrix material. This swelling is reversible but the cristae do not completely re-form and have a blebbed appearance. On repeat...
متن کاملStudies of copper ion-induced mitochondrial swelling in vitro.
1. A study of the mode and mechanism of Cu(2+)-induced mitochondrial swelling was carried out. 2. Mitochondrial swelling curves (E(520) turbidity changes) were obtained as a function of [Cu(2+)], pH, temperature and mitochondrial protein concentration. ED(50) was approx. 70mmumoles of Cu(2+). Calculation of the activation energy from the Arrhenius equation gave a value of 22900cal./mole per deg...
متن کاملThe effect of triethyltin on mitochondrial swelling.
Triethyltin induces swelling of isolated rat liver mitochondria suspended in sucrose or KC1 media. This effect is not seen with brain mitochondria. Triethyltin swelling is only minimally reduced by EDTA or amytal but is prevented by 2 :Cdinitrophenol, cyanide or salicylate. The addition of adenosine trior diphosphate causes reversal of the swelling; this effect is potentiated by Mn2+ but not by...
متن کاملMitochondrial Swelling Induced by Glutathione
Reduced glutathione, in concentrations approximating those occurring in intact rat liver, causes swelling of rat liver mitochondria in vitro which is different in kinetics and extent from that yielded by L-thyroxine. The effect is also given by cysteine, which is more active, and reduced coenzyme A, but not by L-ascorbate, cystine, or oxidized glutathione. The optimum pH is 6.5, whereas thyroxi...
متن کاملUltrastructural Studies on Human Myeloma Plasmacytes1
Myeloma plasmacytes were studied in six untreated pa tients to obtain more information on the nuclear ultrastruc tural abnormalities in these cells. Asynchrony of nucleolar, nuclear, and cytoplasmic maturation was frequently ob served in pleomorphic myeloma plasmacytes. Immature and mature myeloma plasmacytes of two patients contained intranuclear rodlets which consisted of fine filaments ar ra...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1970
ISSN: 0306-3283
DOI: 10.1042/bj1180883