Ultrastructural characterization of the optic pathway in a mouse model of neurofibromatosis-1 optic glioma
نویسندگان
چکیده
منابع مشابه
Optic nerve dysfunction in a mouse model of neurofibromatosis-1 optic glioma.
Individuals with neurofibromatosis type 1 (NF1) are prone to develop optic pathway gliomas that can result in significant visual impairment. To explore the cellular basis for the reduced visual function resulting from optic glioma formation, we used a genetically engineered mouse model of Nf1 optic glioma (Nf1+/-(GFAP)CKO mice). We performed multimodal functional and structural analyses both be...
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Mouse models of human cancers afford unique opportunities to evaluate novel therapies in preclinical trials. For this purpose, we analyzed three genetically engineered mouse (GEM) models of low-grade glioma resulting from either inactivation of the neurofibromatosis-1 (Nf1) tumor suppressor gene or constitutive activation of KRas in glial cells. Based on tumor proliferation, location, and penet...
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Neurofibromatosis type 1 is a common neurogenetic disorder characterized by significant clinical variability. As such, numerous studies have focused on identifying clinical, radiographic, or molecular biomarkers that predict the occurrence or progression of specific clinical features in individuals with neurofibromatosis type 1. One of these clinical biomarkers, macrocephaly, has been proposed ...
متن کاملOptic nerve glioma in neurofibromatosis-I.
A ten-year-old girl presented with swelling on left upper eyelid, multiple hyper pigmented macules and small nodular swellings with hair growth all over the body since birth. Examination revealed hyper pigmented macules >1 cm in diameter, numerous in numbers on both legs. Hyper pigmented nodular lesion was noted in left temporofacial area and swelling on left upper eyelid with restricted upward...
متن کاملNon-optic glioma in adults and children with neurofibromatosis 1
BACKGROUND Non-optic gliomas occur in 5% of children with NF1, but little is known about these tumours in adults. We aimed to investigate progression, spontaneous regression and the natural history of non-optic gliomas in adults and compare these findings to the results found in children. RESULTS One thousand seven hundred twenty-two brain MRI scans of 562 unselected individuals with NF1 were...
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ژورنال
عنوان ژورنال: Neuroscience
سال: 2010
ISSN: 0306-4522
DOI: 10.1016/j.neuroscience.2010.06.017