Ultrasound temperature control during short-term local heating of a test object by focused ultrasound

Online temperature control of focused ultrasound heating using an adaptive PID feedback loop

Introduction Focused ultrasound induced heating for use in thermal therapy requires reliable temperature control to assure safety and therapeutic accuracy. MR thermometry based on the proton resonance frequency shift (PRFS) [1] in combination with a proportional, integral, derivative (PID) feedback control [2] has been suggested as a precise solution for controlling high intensity focused ultra...

Enhancement of High-Intensity Focused Ultrasound Heating by Short-Pulse Generated Cavitation

A target tissue can be thermally coagulated in high-intensity focused ultrasound (HIFU) treatment noninvasively. HIFU thermal treatments have been clinically applied to various solid tumors. One of the problems in HIFU treatments is a long treatment time. Acoustically driven microbubbles can accelerate the ultrasonic heating, resulting in the significant reduction of the treatment time. In this...

Temperature distributions in tissues during local hyperthermia by stationary or steered beams of unfocused or focused ultrasound.

Temperature distributions resulting from insonation with stationary or steered beams of unfocused or focused ultrasound were measured in tissue-equivalent phantom, beef muscle in vitro, dog muscle mass, and transplanted murine tumours in vivo. Arrays of 4 to 6 thermocouples stepped through the volume of interest under computer control were used to measure the steady-state temperatures at 600 to...

Enhanced-heating effect during photoacoustic imaging-guided high-intensity focused ultrasound

Blood Brain Barrier Disruption by Focused Ultrasound and Microbubbles: A Numerical Study on Mechanical Effects

Introduction: Microbubbles are widely used as contrast agent in diagnostic ultrasound. Recently they have shown good potential for applications in the therapeutic field such as drug delivery to the brain. Recent studies have shown focused ultrasound in conjunction with injected micro-bubbles could temporarily disrupt blood-brain barrier and let therapeutic agents transport into...