Tyrosine Phosphorylation Regulates Maturation of Receptor Tyrosine Kinases

Maturation of Receptor Tyrosine Kinases Tyrosine Phosphorylation Regulates

Tyrosine Phosphorylation of CD13 Regulates

Evolution of Receptor Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are important molecules for communication of cells in multicellular animals. It is therefore not surprising that the basal metazoans, like Hydra and sponges, already have a well-developed repertoire of RTKs. Even the choanofl agellate Monosiga brevicollis , a unicellular eukaryote from a group of protozoa that are thought to represent the ancestors of metazoa or...

Tyrosine phosphorylation of glutamate receptors by non-receptor tyrosine kinases: roles in depression-like behavior.

Several key members of the non-receptor tyrosine kinase (nRTK) family are abundantly present within excitatory synapses in the mammalian brain. These neuron-enriched nRTKs interact with glutamate receptors and phosphorylate the receptors at tyrosine sites. The N-methyl-D-aspartate receptor is a direct substrate of nRTKs and has been extensively investigated in its phosphorylation responses to n...

Tyrosine phosphorylation and regulation of the AMPA receptor by SRC family tyrosine kinases.

Phosphorylation of AMPA receptors is a major mechanism for the regulation of receptor function and underlies several forms of synaptic plasticity in the CNS. Although serine and threonine phosphorylation of AMPA receptors has been well studied, the potential role of tyrosine phosphorylation of AMPA receptors has not been investigated. Here, we show that the GluR2 subunit of AMPA receptors is ty...