Tyrosine Phosphorylation of Nicotinic Acetylcholine Receptor Mediates Grb2 Binding
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چکیده
منابع مشابه
Tyrosine phosphorylation of nicotinic acetylcholine receptor mediates Grb2 binding.
Tyrosine phosphorylation of the nicotinic acetylcholine receptor (AChR) is associated with an altered rate of receptor desensitization and also may play a role in agrin-induced receptor clustering. We have demonstrated a previously unsuspected interaction between Torpedo AChR and the adaptor protein Grb2. The binding is mediated by the Src homology 2 (SH2) domain of Grb2 and the tyrosine-phosph...
متن کاملComparison of innervation and agrin-induced tyrosine phosphorylation of the nicotinic acetylcholine receptor.
Studies of the regulation of tyrosine phosphorylation at the neuromuscular junction during development and following denervation suggest that tyrosine phosphorylation of the nicotinic acetylcholine receptor is regulated by neuronal innervation of muscle. The finding that agrin, a neuronally derived extracellular matrix protein also induces tyrosine phosphorylation of the nicotinic receptor, sug...
متن کاملPhosphorylation of the nicotinic acetylcholine receptor by an endogenous tyrosine-specific protein kinase.
Postsynaptic membranes from the electric organ of Torpedo californica, rich in the nicotinic acetylcholine receptor, were shown to contain an endogenous tyrosine protein kinase. This endogenous kinase phosphorylated three major proteins with molecular masses corresponding to 50 kDa, 60 kDa, and 65 kDa. The phosphorylation of these three proteins occurred exclusively on tyrosine residues under t...
متن کاملThe nicotinic acetylcholine receptor at the neuromuscular junction: assembly and tyrosine phosphorylation.
The nicotinic acetylcholine receptor at the neuromuscular junction: assembly and tyrosine phosphorylation.
متن کاملAutoregulation of phosphorylation of the nicotinic acetylcholine receptor.
We have investigated the regulation of phosphorylation of the nicotinic ACh receptor (nAChR) in rat myotubes by the agonist carbamylcholine. Treatment of primary rat myotube cultures with carbamylcholine resulted in a 100% increase in phosphorylation of the nAChR gamma- (52 kDa) subunit and a 30% increase in phosphorylation of the nAChR delta- (62 kDa) and delta'- (66 kDa) subunits. These respo...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 1997
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.17-13-05038.1997