Type II NKT cells differentially regulate CD4 T cell subsets
نویسندگان
چکیده
منابع مشابه
Type II NKT cells differentially regulate CD4 T cell subsets
Natural killer T (NKT) cells lie at the interface between the innate and adaptive immune systems and are important mediators of tumor immunosurveillance. This CD1d-restricted lymphoid population recognizes lipid antigen and can rapidly produce an array of cytokines and chemokines to modulate the host immune response. In tumor immunity, two NKT cell subsets (type I and type II) have contrasting ...
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CD4+CD25+ regulatory T cells play an important role in peripheral tolerance. These cells have been reported to be capable of suppressing the response of CD4+CD25- T cells in vitro. The depletion of these cells evokes effective immune responses to tumor cells in vivo. In this study, we demonstrate that CD4+CD25+ T cells also suppress all subsets of Valpha24+NKT cells (Valpha24+CD4-CD8- double ne...
متن کاملHuman invariant NKT cell subsets differentially promote differentiation , antibody production and T cell stimulation by B cells in vitro 1
Invariant natural killer T (iNKT) cells can provide help for B cell activation and antibody production. Since B cells are also capable of cytokine production, antigen presentation and T cell activation, we hypothesized that iNKT cells will also influence these activities. Furthermore, subsets of iNKT cells based on CD4 and CD8 expression that have distinct functional activities may differential...
متن کاملHuman invariant NKT cell subsets differentially promote differentiation, antibody production, and T cell stimulation by B cells in vitro.
Invariant NK T (iNKT) cells can provide help for B cell activation and Ab production. Because B cells are also capable of cytokine production, Ag presentation, and T cell activation, we hypothesized that iNKT cells will also influence these activities. Furthermore, subsets of iNKT cells based on CD4 and CD8 expression that have distinct functional activities may differentially affect B cell fun...
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ژورنال
عنوان ژورنال: Journal for ImmunoTherapy of Cancer
سال: 2014
ISSN: 2051-1426
DOI: 10.1186/2051-1426-2-s3-p233