Two Types of Prothrombin in Vitamin K Deficiency
نویسندگان
چکیده
منابع مشابه
Vitamin K and the Biosynthesis of Prothrombin
Highly purified dicoumarol-induced bovine prothrombin, which does not bind calcium ions and has no prothrombin activity, has been structurally compared with normal prothrombin. Quantitative amino acid and carbohydrate analysis gave identical results for both prothrombins, as did analysis of the NHz-terminal and the COOH-terminal amino acids and molecular weight determination with the sodium dod...
متن کاملVitamin K and the Biosynthesis of Prothrombin
Highly purified dicoumarol-induced bovine prothrombin, which does not bind calcium ions and has no prothrombin activity, has been structurally compared with normal prothrombin. Quantitative amino acid and carbohydrate analysis gave identical results for both prothrombins, as did analysis of the NHz-terminal and the COOH-terminal amino acids and molecular weight determination with the sodium dod...
متن کاملBleeding Tendency and Prothrombin Deficiency in Biliary Fistula Dogs: Effect of Feeding Bile and Vitamin K
In biliary fistula dogs the plasma prothrombin falls eventually to low levels and bleeding commonly occurs. Faulty absorption of vitamin K from the intestine in these animals is an important causative factor. Feeding bile permits absorption of the traces of this vitamin normally present in mixed diets, and as a result a slow rise in prothrombin level is observed. If a standard diet is supplemen...
متن کاملVitamin K and the Biosynthesis of Prothrombin V. -pCARBOXYGLUTAMIC ACIDS, THE VITAMIN K-DEPENDENT STRUCTURES IN PROTHROMBIN*
Tryptic peptides obtained from normal prothrombin have been compared with those obtained from prothrombin synthesized by cattle given the vitamin K antagonist dicumarol. Two peptides were found which contain vitamin K-dependent structures. These peptides contain residues 4 through 10 and residues 12 through 44, respectively. One of these (residues 4 through 10) has previously been shown to cont...
متن کاملVitamin K and the biosynthesis of prothrombin. V. Gamma-carboxyglutamic acids, the vitamin K-dependent structures in prothrombin.
Tryptic peptides obtained from normal prothrombin have been compared with those obtained from prothrombin synthesized by cattle given the vitamin K antagonist dicumarol. Two peptides were found which contain vitamin K-dependent structures. These peptides contain residues 4 through 10 and residues 12 through 44, respectively. One of these (residues 4 through 10) has previously been shown to cont...
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ژورنال
عنوان ژورنال: Thrombosis and Haemostasis
سال: 1970
ISSN: 0340-6245,2567-689X
DOI: 10.1055/s-0038-1654194