Two New Meliacarpinins from the Roots of Melia azedarach.

Potent limonoid insect antifeedant from Melia azedarach.

Systematic fractionation of a fruit extract from Argentine Melia azedarach L., which was monitored by an insect antifeedant bioassay, led to the isolation of meliartenin, a limonoid antifeedant, which existed as a mixture of two interchangeable isomers. At 4 microg/cm2 and 1 microg/cm2, the isomeric mixture was as active as azadirachtin in strongly inhibiting the larval feeding of Epilachna pae...

Cytotoxic tirucallane triterpenoids from Melia azedarach fruits.

The phytochemical investigation of the dichloromethane-soluble part of the methanol extract obtained from the fruits of Melia azedarach afforded one new tirucallane-type triterpene, 3-alpha-tigloylmelianol and three known tirucallanes, melianone, 21-beta-acetoxy-melianone, and methyl kulonate. The structure of the isolated compounds was mainly determined by 1D and 2D NMR experiments as well as ...

An antiviral meliacarpin from leaves of Melia azedarach L.

Bioassay guided purification of the ethyl acetate extract of leaves of Melia azedarach led to the isolation of the limonoid 1-cinnamoyl-3,11-dihydroxymeliacarpin, which showed IC50 values of 6 microM and 20 microM for vesicular stomatitis (VSV) and herpes simplex (HSV-1) viruses, respectively. Its structure was established by spectroscopic methods.

Evaluation of Hydroalcoholic Extract of Melia Azedarach Linn Roots for Analgesic and Anti-Inflammatory Activity

Natural products, including plants, animals and minerals have been the basis of treatment of human diseases. Melia azedarach L, commonly known as mahanimba belongs to family Meliaceae. It is large evergreen tree found throughout India and very similar to neem. Traditionally it is used as anthelmintic, antilithic diuretic, astringent and stomachic [1]. Various scientific studies reported the ant...

Anti-moulting activity in Brazilian Melia azedarach.