Two-dimensional liquid chromatography system for online top-down mass spectrometry
نویسندگان
چکیده
منابع مشابه
Online Hydrophobic Interaction Chromatography-Mass Spectrometry for Top-Down Proteomics.
Recent progress in top-down proteomics has led to a demand for mass spectrometry (MS)-compatible chromatography techniques to separate intact proteins using volatile mobile phases. Conventional hydrophobic interaction chromatography (HIC) provides high-resolution separation of proteins under nondenaturing conditions but requires high concentrations of nonvolatile salts. Herein, we introduce a s...
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ژورنال
عنوان ژورنال: PROTEOMICS
سال: 2010
ISSN: 1615-9853
DOI: 10.1002/pmic.201000367