Two components of blood-brain barrier disruption in the rat

Quantitative evaluation of Blood Brain Barrier permeability in transient focal cerebral ischemia in the rat

Introduction: Development of brain edema following focal cerebral ischemia exacerbates primary ischemic injury. Blood brain barrier (BBB) opening is an important part of edema named as vasogenic brain edema. In this study, quantitative alterations of BBB permeability is experimentally evaluated using transient focal cerebral ischemia in the rat. Methods: Two groups of male rats (ischemic and sh...

Blood-brain barrier disruption in multiple sclerosis.

The blood-brain barrier (BBB) is a complex organization of cerebral endothelial cells (CEC), pericytes and their basal lamina, which are surrounded and supported by astrocytes and perivascular macrophages. Collectively these cells separate and form the compartments of the cerebral vascular space and the cerebral interstitium under normal conditions. Without the BBB, the 'interior milieu' of the...

P6: Neuroprotective Effect of Estrogen against Brain Edema and Blood Brain Barrier Disruption: Roles of Estrogen Receptors α and β

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Consequences of blood-brain barrier disruption

Blood-brain barrier disruption after cardiac surgery.

BACKGROUND AND PURPOSE CNS complications are often seen after heart surgery, and postsurgical disruption of the BBB may play an etiologic role. The objective of this study was to determine the prevalence of MR imaging-detected BBB disruption (HARM) and DWI lesions after cardiac surgery. MATERIALS AND METHODS All patients had an MRI after cardiac surgery. For half the patients (group 1), we ad...