Two- and Three-Locus Tests for Linkage Analysis Using Recombinant Inbred Lines
نویسندگان
چکیده
منابع مشابه
Two- and three-locus tests for linkage analysis using recombinant inbred lines.
We consider fixed recombinant inbred lines (RILs) derived either by selfing or by full-sib mating; when applicable, we also consider intermated recombinant inbreds (IRIs). First, we show that the usual estimate of recombination fraction based on RIL data is biased, and we provide an estimate where the major part of that bias is removed. Second, we derive simple formulas to compute the frequenci...
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ژورنال
عنوان ژورنال: Genetics
سال: 2006
ISSN: 1943-2631
DOI: 10.1534/genetics.105.047175