Twenty years of limbal epithelial therapy: an update on managing limbal stem cell deficiency
نویسندگان
چکیده
منابع مشابه
Minimal conjunctival limbal autograft for total limbal stem cell deficiency.
PURPOSE To report the results of one 60 degrees conjunctival limbal autograft (CLAU) combined with amniotic membrane (AM) transplantation for an eye with total limbal stem cell deficiency (LSCD). METHODS One eye of a patient with chronic total LSCD and symblepharon caused by chemical burn was subjected to symblepharon lysis, removal of pannus from corneal surface, AM transplantation to cover ...
متن کاملAllo-limbal transplantation in patients with limbal stem cell deficiency.
AIM To report the outcome of a series of patients with stem cell deficiency who underwent allo-limbal transplantation and to describe a technique for this procedure. METHODS Six consecutive patients underwent allo-limbal stem cell transplantation. The primary diagnosis included alkali burn (n = 2), trachoma (n = 1), chronic rosacea blepharitis and kerato-conjunctivitis (n = 1), aniridia (n = ...
متن کاملManagement of Unilateral Limbal Stem Cell Deficiency by Simple Limbal Epithelial Transplantation – Our Experience
Simple Limbal Epithelial Transplantation (SLET) has been proposed recently for care of total Limbal Stem Cell Deficiency (LSCD) secondary to alkali burn of cornea [1]. Reportedly it combines advantages of conjunctival limbal auto grafting [2] and cultivated limbal epithelial transplantation [3] by being a single-stage, affordable procedure utilizing minimal donor tissue. Besides, it is also rep...
متن کاملPre-Clinical Cell-Based Therapy for Limbal Stem Cell Deficiency
The cornea is essential for normal vision by maintaining transparency for light transmission. Limbal stem cells, which reside in the corneal periphery, contribute to the homeostasis of the corneal epithelium. Any damage or disease affecting the function of these cells may result in limbal stem cell deficiency (LSCD). The condition may result in both severe pain and blindness. Transplantation of...
متن کاملPhenotypic study after cultivated limbal epithelial transplantation for limbal stem cell deficiency.
OBJECTIVE To report phenotypic analysis of epithelia before and following cultivated limbal epithelial transplantation (CLET) for eyes with limbal stem cell deficiency. METHODS Six patients with limbal stem cell deficiency (3 with alkali burns, 2 with Stevens-Johnson syndrome, and 1 with pseudo-ocular cicatricial pemphigoid) were subjected to CLET and subsequent keratoplasty. Immunohistochemi...
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ژورنال
عنوان ژورنال: BMJ Open Ophthalmology
سال: 2018
ISSN: 2397-3269
DOI: 10.1136/bmjophth-2018-000164