Turnover of individual cholesterol esters in human liver and plasma.

Turnover of individual cholesterol esters in human liver and plasma.

There are several lines of evidence which suggest that the liver is a major source of plasma cholesterol esters. First, eviscerated rats cannot maintain a normal concentration of cholesterol esters in the plasma (1); second, when isotopically labeled mevalonic acid is administered to rats, the specific radioactivity of the hepatic cholesterol esters initially exceeds that of the plasma choleste...

The in Vivo Turnover of Individual Cholesterol Esters in Human Plasma Lipoproteins.

Turnover of plasma cholesterol in man.

Cholesterol-4-(14)C was injected intravenously into a series of normal men, untreated hyperlipidemic patients, and hyperlipidemic patients being treated with cholestyramine. The specific radioactivity of plasma total cholesterol was measured during the ensuing 10 wk. 16 studies were carried out in 10 subjects. Analysis of the turnover curves of plasma cholesterol revealed that in every study th...

Relationship between total cholesterol and cholesteryl esters with age in human blood plasma.

E VIDENCE CONTINUES to accumulate in support of the concept that the serum cholesterol level may be influenced by the dietary intake of cholesterol and the type and amount of fat in the diet; other factors such as the dietary intake of simple sugars, age, exercise, weight, and metabolic abnormalities such as diabetes mellitus may also be influential. It is also generally agreed that elevations ...

Endogenous triglyceride turnover in liver and plasma of the dog.

Radioactive glycerol and S(f) > 20 lipoproteins labeled with it were used to study turnover of plasma S(f) > 20 and hepatic triglyceride in anesthetized dogs. From specific activity-time curves of these lipids after an injection of labeled material, a tentative and incomplete model for the kinetics of endogenous hepatic and plasma triglyceride was defined and partially validated. Pool sizes and...