Türk kadınlarında MDR1 (ABCB1) geni C3435T, C1236T, G2677T/A, A2956G polimorfizmleri ile meme kanseri riski arasındaki ilişki
نویسندگان
چکیده
منابع مشابه
Analysis of common MDR1 (ABCB1) gene C1236T and C3435T polymorphisms in Turkish patients with familial Mediterranean fever.
The multidrug resistance (MDR1) gene encodes a P-glycoprotein that plays a key role in drug bioavailability and response to drugs in different human populations. More than 50 SNPs have been described for the MDR1 gene. Familial Mediterranean fever (FMF) is considered an autosomal recessive hereditary disease, associated with a single gene named the Mediterranean fever gene (MEFV). However,...
متن کاملFrequency of the C1236T, G2677T/A and C3435T MDR1 gene polymorphisms in the Serbian population.
The multi-drug resistance 1 (MDR1) gene encodes for a P-glycoprotein (PGP), which acts as a gate-keeper against various kinds of xenobiotics. Several single nucleotide polymorphisms (SNPs) in the MDR1 gene that may influence PGP level and function have been identified. The aim of this study was to simultaneously analyze the three most important MDR1 SNPs, C3435T, G2677T/A and C1236T, in the Ser...
متن کاملABCB1 C1236T, G2677T/A and C3435T polymorphisms in systemic lupus erythematosus patients.
P-glycoprotein (Pgp), the ABCB1 gene product, acts as an efflux pump that transports a large variety of substrates and is a mechanism of cell protection against xenobiotics. An increasing number of studies have shown that some ABCB1 polymorphisms may affect Pgp expression and activity, as well as affecting the development and susceptibility to diseases and pharmacological response. High activit...
متن کاملMDR1 C3435T and C1236T polymorphisms: association with high-risk childhood acute lymphoblastic leukemia.
BACKGROUND MDR1, one of the most important drug-transporter genes, encodes P- glycoprotein (P-gp)-a transporter involved in protecting against xenobiotics and multi-drug resistance. The significance of the genetic background in childhood acute lymphoblastic leukemia (ALL) is not well understood. MATERIALS AND METHODS To evaluate whether C3435T and C1236T MDR1 polymorphisms are associated with...
متن کاملABCB1 (MDR1, P-Glycoprotein) C3435T Gene Polymorphism and its Possible Association with Chronic Myeloid Leukemia Prognosis
Adenosine triphosphate-binding cassette B1 (MDR1multiple drug resistance gene1), a drug transporter gene encodes a transmembrane glycoprotein (P-gp), which functions as an efflux pump for various structurally unrelated anticancer agents and toxins. Our main objective is to study MDR1 gene polymorphism at C3435T in chronic myeloid leukemia (CML) to understand its association with development and...
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ژورنال
عنوان ژورنال: SDÜ Tıp Fakültesi Dergisi
سال: 2022
ISSN: 1300-7416
DOI: 10.17343/sdutfd.650471