منابع مشابه
Reversible covalent inhibition of eEF-2K by carbonitriles.
eEF-2K is a potential target for treating cancer. However, potent specific inhibitors for this enzyme are lacking. Previously, we identified 2,6-diamino-4-(2-fluorophenyl)-4H-thiopyran-3,5-dicarbonitrile (DFTD) as an inhibitor of eEF-2K. Here we describe its mechanism of action against eEF-2K, on the basis of kinetic, mutational, and docking studies, and use chemoinformatic approaches to identi...
متن کاملPhosphorylation of elongation factor-2 kinase on serine 499 by cAMP-dependent protein kinase induces Ca2+/calmodulin-independent activity.
Elongation factor-2 kinase (eEF-2K) negatively regulates mRNA translation via the phosphorylation and inactivation of elongation factor-2 (eEF-2). We have shown previously that purified eEF-2K can be phosphorylated in vitro by cAMP-dependent protein kinase (PKA) and that this induces significant Ca(2+)/calmodulin (CaM)-independent eEF-2K activity [Redpath and Proud (1993) Biochem. J. 293, 31-34...
متن کاملResistive CAM Acceleration for Tunable Approximate Computing
The Internet of Things significantly increases the amount of data generated, straining the processing capability of current computing systems. Approximate computing is a promising solution to accelerate computation by trading off energy and accuracy. In this paper, we propose a resistive content addressable memory (CAM) accelerator, called RCA, which exploits data locality to have an approximat...
متن کاملAnalysis of the domain structure of elongation factor-2 kinase by mutagenesis.
A number of elongation factor-2 kinase (eEF-2K) mutants were constructed to investigate features of this kinase that may be important in its activity. Typical protein kinases possess a highly conserved lysine residue in subdomain II which follows the GXGXXG motif of subdomain I. Mutation of two lysine residues, K340 and K346, which follow the GXGXXG motif in eEF-2K had no effect on activity, sh...
متن کاملA Combinatorial Proof of a Relationship Between Maximal $(2k-1, 2k+1)$-Cores and $(2k-1, 2k, 2k+1)$-Cores
Integer partitions which are simultaneously t–cores for distinct values of t have attracted significant interest in recent years. When s and t are relatively prime, Olsson and Stanton have determined the size of the maximal (s, t)-core κs,t. When k > 2, a conjecture of Amdeberhan on the maximal (2k − 1, 2k, 2k + 1)-core κ2k−1,2k,2k+1 has also recently been verified by numerous authors. In this ...
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ژورنال
عنوان ژورنال: Structure
سال: 2016
ISSN: 0969-2126
DOI: 10.1016/j.str.2016.08.005