Tumour necrosis factor gene complex polymorphisms in chronic obstructive pulmonary disease
نویسندگان
چکیده
منابع مشابه
Tumour necrosis factor-alpha gene promoter polymorphism in chronic obstructive pulmonary disease.
Tumour necrosis factor(TNF)-alpha levels are elevated in airways of patients with chronic obstructive pulmonary disease (COPD) and may contribute to its pathogenesis. A guanine to adenine substitution at position -308 of the TNF-alpha gene promoter (TNF1/2) has been associated with chronic bronchitis of various aetiologies in a Taiwanese population. The authors performed a study investigating a...
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The genetic component was suggested to contribute to the development of chronic obstructive pulmonary disease (COPD), a major and growing public health burden. The present review aims to characterize the evidence that gene polymorphisms contribute to the aetiology of COPD and related traits, and explore the potential relationship between certain gene polymorphisms and COPD susceptibility, sever...
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STUDY OBJECTIVE The pathogenesis of chronic obstructive pulmonary disease (COPD) is characterized by an interaction of environmental influences, particularly cigarette smoking, and genetic determinants. Given the global increase in COPD, research on the genomic variants that affect susceptibility to this complex disorder is reviving. In the present study, we investigated whether single nucleoti...
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A E Hegab, T Sakamoto, Y Uchida, A Nomura, Y Ishii, Y Morishima, M Mochizuki, T Kimura, W Saitoh, H H Massoud, H M Massoud, K M Hassanein, K Sekizawa . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ....
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Background :Chronic obstructive pulmonary disease (COPD) is a third leading cause of death. Methods : In this case control study, we prepared 5 cc bloods from the antecubital vein of 100 COPD patients and 40 healthy individuals as control group. Vascular endothelial growth factor (VEGF) expression protein level was measured by ELISA in both groups. Results : We found that concentration of...
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ژورنال
عنوان ژورنال: Respiratory Medicine
سال: 2007
ISSN: 0954-6111
DOI: 10.1016/j.rmed.2006.05.017