منابع مشابه
Signal transduction by tumour necrosis factor and tumour necrosis factor related ligands and their receptors.
Many biological functions are regulated through interactions of extracellular molecules with their cognate cell surface receptors. The transduction of these signals by their receptors at the plasma membrane to the intracellular machinery results in such cellular activities as gene activation, protein phosphorylation, cell proliferation, and cell destruction. Though the kinetics of these activit...
متن کاملPentoxifylline and tumour necrosis factor-induced
Acute Gram-negative bacterial infections evoke characteristic pathophysiological responses, including changes in white blood cell counts, fever, haemodynamic disorders, and various coagulatory disturbances, which may result in respiratory distress syndrome, multiorgan failure and irreversible shock. It is generally accepted that endotoxins, the lipopolysaccharides (LPS) of Gramnegative bacteria...
متن کاملTumour necrosis factor-α in nasal allergy
Tumour necrosis factor-alpha (TNF-alpha) was measured by enzyme-linked immunosorbent assay and eosinophil cationic protein (ECP) by radio-immunoassay to evaluate TNF-alpha in nasal allergy. There was no significant difference either between the mean concentrations of TNF-alpha in nasal secretions from the patients with perennial nasal allergy and those of normal subjects, or between the TNF-alp...
متن کاملTumour necrosis factor haplotypes and asthma.
Airway inflammation is a prominent feature of asthma. The pro-inflammatory cytokine Tumour Necrosis Factor shows constitutional variation in its level of secretion, which is linked to polymorphisms within the TNF gene complex and the surrounding MHC. In this study, 413 subjects in 88 nuclear families from a general population sample were examined for association with asthma and TNF polymorphism...
متن کاملTumour necrosis factor in synovial exudates
The actions of tumour necrosis factor (TNF) include resorption of bone and cartilage, suggesting a potential role in the pathogenesis of arthritis. TNF activity was looked for in synovial fluids from 137 patients with different rheumatic diseases. Unfractionated samples were tested in the L929 bioassay. Significant TNF activity that was neutralised by monoclonal antibody to TNF alpha occurred i...
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ژورنال
عنوان ژورنال: BMJ
سال: 1988
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.296.6631.1214