Tumor Vasculature Targeting: A Generally Applicable Approach for Functionalized Nanomaterials
نویسندگان
چکیده
منابع مشابه
Targeting Established Tumor Vasculature: A Novel Approach to Cancer Treatment
The selective targeting of established tumor vasculature represents an attractive new anticancer drug strategy, distinct from inhibiting angiogenesis. This is based on the concept that, in contrast to targeting individual tumor cells, the killing of relatively few vascular endothelial cells could result in the death of a large area of tumor (from lack of oxygen and nutrients), drug delivery to ...
متن کاملTargeting tumor vasculature with aptamer-functionalized doxorubicin-polylactide nanoconjugates for enhanced cancer therapy.
An A10 aptamer (Apt)-functionalized, sub-100 nm doxorubicin-polylactide (Doxo-PLA) nanoconjugate (NC) with controlled release profile was developed as an intravenous therapeutic strategy to effectively target and cytoreduce canine hemangiosarcoma (cHSA), a naturally occurring solid tumor malignancy composed solely of tumor-associated endothelium. cHSA consists of a pure population of malignant ...
متن کاملThioaptamer Conjugated Liposomes for Tumor Vasculature Targeting
Recent developments in multi-functional nanoparticles offer a great potential for targeted delivery of therapeutic compounds and imaging contrast agents to specific cell types, in turn, enhancing therapeutic effect and minimizing side effects. Despite the promise, site specific delivery carriers have not been translated into clinical reality. In this study, we have developed long circulating li...
متن کاملHyGLEAM - An Approach to Generally Applicable Hybridization of Evolutionary Algorithms
Most successful applications of Evolutionary Algorithms to real world problems employ some sort of hybridization, thus speeding up the optimization process but turning the general applicable Evolutionary Algorithm into a problem-specific tool. This paper proposes to combine Evolutionary Algorithms and generally applicable local searchers to get the best of both approaches: A fast, but robust to...
متن کاملVulnerability: A generally applicable conceptual framework for climate change research
The term ‘vulnerability’ is used in many different ways by various scholarly communities. The resulting disagreement about the appropriate definition of vulnerability is a frequent cause for misunderstanding in interdisciplinary research on climate change and a challenge for attempts to develop formal models of vulnerability. Earlier attempts at reconciling the various conceptualizations of vul...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Small
سال: 2014
ISSN: 1613-6810
DOI: 10.1002/smll.201303627